Novel Targets in Treating Erectile Dysfunction
Courtesy Lysiak, Palmer, Kavoussi Figure 1. Heterozygote and knockout mice are unable to maintain erections. When the cavernous nerve is stimulated, wild type mice (blue) are able to maintain high...
View ArticleSept6 Antibody
Production and Reactivity This mouse monoclonal antibody was generated against a tetramer of GST-BD3/Sept2/Sept6/Sept7 and recognizes human and canine homologs of Sept6.Clone number9E7ApplicationsWB,...
View ArticleSIMPLE: A Novel Immunohistochemical Method for Multiple Antigen Labeling
Executive Summary A new method for immunohistochemical (IHC) staining allowing colocalization studies of six or more proteins within a single tissue section.Background Visual colocalization of...
View ArticleDiabetes-Resistant Mouse Strains
Reagent DescriptionThese mouse strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD/Bdc background. These strains experience significantly reduced diabetes and are...
View ArticleCrohn's Disease Mouse Model
Reagent DescriptionSAMP1/YitFcs (also called SAMP1/YitFc or SAMP1/Fc) mice develop a spontaneous ileitis that is similar in many features to human Crohn’s disease. Development of ileitis is accelerated...
View ArticleCircadian Rhythm-Induced Luciferase Expression in a Rat Strain
Reagent DescriptionThis rat strain is useful for studying the organization of the mammalian circadian system. In this transgenic rat line, luciferase is rhythmically expressed under the control of the...
View ArticleGnRH Neuron GFP-Expressing Mouse Strain
Reagent DescriptionThis transgenic mouse line expresses the reporter green fluorescent protein (GFP) under the control of the mouse gonadotrophin-releasing hormone (GnRH) promoter. This allows the...
View ArticleNeutrophil-Specific, NIR Fluorescent Imaging Agent
Courtesy of Pan, Zhang, Xiao This figure shows NIR fluorescence image three hours after injection of cFLFLF-PEG76-Cy7 in a mouse model of ear inflammation. (A) shows probe accumulation in the...
View ArticlePhospho-Tyrosine Antibody
Production and Reactivity This mouse IgG2a antibody was generated against tyrosine phospho-proteins purified from chicken embryonic fibroblasts (CEFs) expressing pp60/c-src 527F and 2A/527F and...
View Articlep120/Catenin Antibody (Clone 2B12)
Production and Reactivity This mouse IgG1 antibody was generated against tyrosine phosphoproteins purified from chicken embryonic fibroblasts (CEFs) expressing pp60/c-src 527F and 2A/527F. It...
View ArticleAndrogen Receptor Antibody (AR21)
Production and Reactivity This rabbit polyclonal antibody was generated against the N-terminal 21 amino acids of human androgen receptor (AR).ApplicationsWB, IP, IFReferencesMol Cell Biol. 2007...
View ArticleSno Knockout Mouse Strain
Reagent DescriptionThese mutant mice may be useful in studies of T cell activation, T cell receptor stimulation and TGF-beta signaling. A targeting vector was designed to replace exon 1 of the...
View ArticleDynein Light Chain 3 (DYNLT3) Antibody
Production and Reactivity This mouse IgG2a monoclonal antibody was generated against rat Dynein Light Chain 3 (DYNLT3) and recognizes rat and human homologs.Clone Number10A3-C8-A1ApplicationsWB,...
View ArticleDynein Light Chain 1 (DYNLT1) Antibody
Production and Reactivity This mouse IgG1 monoclonal antibody was generated against human Dynein Light Chain 1 (DYNLT1) and recognizes rat and human homologs.Clone Number7A9-F4-H10ApplicationsWB,...
View ArticleCytoplasmic Dynein Intermediate Chain Antibody (Clone 74.1)
Production and Reactivity: IgG2b mouse monoclonal antibody generated against bovine brain cytoplasmic dynein and recognizes an epitope in the N-terminal 60 amino acids of the intermediate chain (IC)...
View ArticleAmorphous Steel Composites and Methods for Their Manufacture
Amorphous steels exhibit superb mechanical properties for a variety of high-performance applications, but they are significantly more brittle than conventional high-carbon steels. The fracture...
View ArticleLightweight Structures for Improving Performance of Aerospace Components
Invention DescriptionAerospace vehicles have many components that are subjected to high thermal and mechanical loading. In addition to heat and strength considerations, these components must be...
View ArticleAn Improved Method for Diagnosing Seizures
Executive SummaryThe invention is a novel patient-monitoring device that uses limb accelerometry to more accurately diagnose epileptic seizures (ES).BackgroundNearly 10 percent of Americans will...
View ArticleHigh Sensitivity Infrared Sensing Apparatus
Researchers at the University of Virginia have developed a novel idea for IR sensor system design where the detector is suspended away from electrical and thermal connections. Sensitivity of such a...
View ArticleRhoG Antibody
Production and Reactivity This mouse IgG2a monoclonal antibody was generated against amino acids 161–180 of RhoG and recognizes human, mouse and rat homologs.Clone Number1F3-B3-E5ApplicationsWB,...
View ArticleZizimin1 (CDC42 GEF) Antibody
Production and Reactivity This mouse IgG2a monoclonal antibody was generated against human zizimin1 and recognizes amino acids 1184-1215 of human and primate homologs.Clone...
View ArticleE. coli LacI Antibody
Production and Reactivity This mouse IgG1 monoclonal antibody was generated against E. coli LacI and recognizes recombinant proteins containing the LacI tag.Clone Number9A5ApplicationsWB, IF,...
View ArticleSuper-Rich Hydrogen Storage Nanomaterials with Intermediate Bond Strength
The quest for vehicles powered by alternative sources of fuel such as hydrogen has led to an explosion of research into new materials for storing and releasing hydrogen. Currently, one of the main...
View ArticlePhospho-Y694/699 STAT5A/B Antibody
Normal 0 false false false MicrosoftInternetExplorer4 Production and Reactivity This chicken antibody was generated against a phospho-peptide of amino acids 690/4-701/6 of human STAT5A/B and...
View ArticleHuman Mast Cell Line Ideal for Inflammation Studies
Executive SummaryThis technology is an immortalized human mast cell line that is easily cultured without growth factors and that has a high expression of FcεRI for investigating inflammation...
View ArticleInverted Well Plate for Large-Scale Cell Culture
Courtesy of Stocks, Peirce-Cottler, Katz Executive Summary This invention is the inverted complement of a 96-well plate made to increase cell transfer efficiency and decrease the time needed for...
View ArticleUse of Monoclonal Antibodies to Target Cancer Cells
The use of monoclonal antibodies in cancer diagnosis and treatment, while promising, is also problematic. Current cancer therapies that rely on this technology require the identification of specific...
View ArticleNovel Technique for More Efficient Vapor Deposition
Executive SummaryThe invention involves a novel process and apparatus that use hollow cathode technology to improve any evaporation-based method for coating the surface of materials.BackgroundVapor...
View ArticleSelf-Integrated Sandwich Panel Design for Improved Strength, Reduced Failure...
Executive SummaryThe invention is a novel concept for eliminating the failure point of current sandwich panels, producing a structure that provides greater strength without an increase in...
View ArticleA Novel Spline-Based Algorithm for Multidimensional Displacement and Strain...
Researchers at the University of Virginia have developed a novel motion estimation algorithm based on a continuous representation of discrete-sample images, with accuracy better than one 100th of a...
View ArticleIntegrative Technique for Improved Signal-to-Noise Ratio in Medical Imaging
Executive SummaryResearchers led by the University of Virginia’s William F. Walker, Ph.D., have developed an angular imaging system that improves the quality and diagnostic potential of medical imaging...
View ArticleMAP Kinase 2 Antibody
Production and Reactivity This mouse IgG2a monoclonal antibody was generated against HPLC purified murine recombinant MAP kinase and recognizes avian, human, mouse and rat homologs.Clone...
View ArticleFLUX SHUTTLE RAM: High-Density Magnetic Random Access Memory
Executive SummaryThe invention is a novel method for achieving magnetic random access memory (MRAM) that enables higher memory densities and faster write speeds while lowering the energy consumed when...
View ArticleMethod and Device for Maximizing Memory System Bandwidth by Accessing Data in...
Microprocessor performance has increased by 50−100 percent per year in the last decade, while DRAM performance has risen only 10−15 percent per year. Memory bandwidth, therefore, is rapidly becoming...
View ArticleNovel Compounds for Prevention and Treatment of Bacterial Infections and...
Executive SummaryUniversity of Virginia researchers have created novel derivative compounds of FDA-approved drug Nitazoxanide (NTZ) that show reduced toxicity, improved bioavailability and greater...
View ArticleNovel Compounds for the Treatment of Diarrheal Diseases
Executive SummaryUniversity of Virginia researchers have created novel derivative compounds of FDA-approved drug Nitazoxanide (NTZ) that show reduced toxicity, improved bioavailability and greater...
View ArticleNovel Atherosclerotic Plaque Detection/Assessment Technique for the Treatment...
Courtesy Meyer Laboratory SPECT/CT imaging (A), phosphor imaging (B) and Sudan IV staining (C). All mice injected with LOX-1 probe had hotspots in the aortic arch (sagittal, coronal and transversal...
View ArticleMultimodality Imaging Probe for Protein Critical to the Development of...
Executive SummaryThe invention is a multimodality imaging probe for detecting the oxidized LDL receptor, LOX-1. The researchers have successfully demonstrated LOX-1 staining using SPECT/CT, MRI and...
View ArticleTASK1 and TASK3 Knockout Mouse Strains
Reagent DescriptionsFive reagents are available: Task1flox: In this strain, the gene for TASK-1 (K2P3.1, Kcnk3) has been flanked by loxP sites in order to support Cre-mediated excision. Targeting...
View ArticleHuman HLA-Expressing Mouse Strains
Reagent DescriptionsTwo reagents are available: HLA-A2.1: This transgenic mouse strain was constructed by microinjection of the 7kb EcoRI fragment containing the full-length HLA-A2.1 gene into...
View ArticleNidogen/Enactin Antibodies
Production and Reactivity: Rat monoclonal antibodies generated against mouse nidogen and recognize mouse and human homologs. Blocks nidogen binding to laminin. Clone number Isotype Epitope...
View ArticleMBP/Beta-Tubulin Fusion Proteins
DescriptionThe isotype-defining domain (C-terminal 16 amino acids) of each class of human beta-tubulin was fused to Maltose Binding Protein (MBP) and expressed in bacteria. The fusion proteins* are...
View ArticleMethod for Efficient Mass-Production of Surface Textures
Courtesy of Gupta laboratory Microscopic view of a laser micro-textured surface. BackgroundSurface texturing has become an important tool for enhancing surface properties, particularly in fields such...
View ArticleBordetella Pertussis Adenylate Cyclase (AC) Toxin Antibody
Production and ReactivityThese mouse monoclonal antibodies have been generated against the purified B. pertussis AC toxin and also recognize other RTX family bacterial toxins (2F5 and 9D4 only). Clone...
View ArticleSMARCAL1 (ATPase A) Antibodies
Production and ReactivityThese mouse monoclonal antibodies were generated against bovine SMARCAL1 and recognize the species indicated below in addition to the bovine homolog. No antibody clone...
View ArticleMultiplex PCR Detection of Viral, Parasite and Bacterial Pathogens
Executive SummaryInfectious disease researchers at the University of Virginia have developed quantitative multiplex RT-PCR assays for the major viral, bacterial, protozoan and helminthes causes of...
View ArticleNuclear Transport Factor 2 (NTF2) Antibodies
Production and ReactivityThese mouse monoclonal antibodies were generated against human NTF2. Clone Number Isotype Antigen Epitope Reactivity 4F5 IgG2b Full length recombinant NTF2 C-terminus Human,...
View ArticleDynein Light Chain 1/3 (DYNLT1/3) Antibodies
Production and Reactivity These mouse IgG1 monoclonal antibodies recognize rat and human homologs of both Dynein Light Chain 1 (DYNLT1) and Dynein Light Chain 3 (DNYLT3).Clone...
View ArticleHuman C3 (Complement Protein) Antibodies
Production and Reactivity These mouse IgG1 monoclonal antibodies were generated against human C3 and recognize mouse and human homologs of C3 and its breakdown products C3b and iC3b.Clone...
View ArticleNovel Dye Improves Breast Cancer Imaging, Detection
Executive Summary Radiology researchers at the University of Virginia and Cedars-Sinai Medical Center have developed novel heptamethine dyes that possess both nuclear and near-infrared imaging...
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